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C57BL/6JGpt-Tg(Thy-APP/Thy-PSEN1)5/Gpt

FAD4T|Strain NO.T053302

Transgenic (Tg)

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BASIC INFORMATION
Strain Name: C57BL/6JGpt-Tg(Thy-APP/Thy-PSEN1)5/Gpt
Strain Number: T053302
Official Symbol: APP,PSEN1
Strain Strategy: T053302.FAD4T strain info.pdf
Official Full Name: amyloid beta precursor protein,presenilin 1
Also Known As: AAA,ABETA,ABPP,AD1,APPI,CTFgamma,CVAP,PN-II,PN2,alpha-sAPP,preA4
NCBI Number: 3515663
Research Areas: Disease Models,Neurodegenerative diseases,Alzheimer's disease
Strain Background: [N000013] C57BL/6JGpt
Modification Type: Transgenic (Tg)
Inventory Status: Live,Cryopreserved
Sale Status: IF (Available for Distribution)
Health Status: Specific pathogen free (SPF)
Health Report: Please log in to view
Publications: 1. Pathological BBB Crossing Melanin-Like Nanoparticles as Metal-Ion Chelators and Neuroinflammation Regulators against Alzheimer's Disease. Research (2023)2. H3K18 lactylation of senescent microglia potentiates brain aging and Alzheimer's disease through the NFkappaB signaling pathway. J Neuroinflammation (2023)3. Targeting aberrant glycosylation to modulate microglial response and improve cognition in models of Alzheimer's disease. Pharmacol Res (2024)4. Mannose-Integrated Nanoparticle Hitchhike Glucose Transporter 1 Recycling to Overcome Various Barriers of Oral Delivery for Alzheimer's Disease Therapy. ACS Nano (2024)5. Novel Social Stimulation Ameliorates Memory Deficit in Alzheimer's Disease Model through Activating alpha-Secretase. JOURNAL OF NEUROSCIENCE (2024)6. SIRT5-Mediated Desuccinylation of RAB7A Protects Against Cadmium-Induced Alzheimer's Disease-Like Pathology by Restoring Autophagic Flux. Advanced Science (2024)7. IL-17A Induces Circadian Disruptions Through the Epigenetic Repression of BMAL1 in Mice With Alzheimer's Disease. J Cell Mol Med (2025)